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47 old drugs to treat Covid-19
#1
Smile  A bit technical, and far above my pay grade.

https://www.nakedcapitalism.com/2020/05/...id-19.html

We Found and Tested 47 Old Drugs That Might Treat the Coronavirus: Results Show Promising Leads and a Whole New Way to Fight COVID-19

Posted on May 2, 2020 by Yves Smith


"Yves here. It is disturbing to watch the push to con the public into seeing remdesivir as the only promising treatment for coronavirus. Please circulate this post widely to inform people you know that established, lower cost drugs also show promise."

By Nevan Krogan, Professor and Director of Quantitative Biosciences Institute & Senior Investigator at the Gladstone Institutes, University of California, San Francisco. Originally published at The Conversation

"The more researchers know about how the coronavirus attaches, invades and hijacks human cells, the more effective the search for drugs to fight it. That was the idea my colleagues and I hoped to be true when we began building a map of the coronavirus two months ago. The map shows all of the coronavirus proteins and all of the proteins found in the human body that those viral proteins could interact with.

In theory, any intersection on the map between viral and human proteins is a place where drugs could fight the coronavirus. But instead of trying to develop new drugs to work on these points of interaction, we turned to the more than 2,000 unique drugs already approved by the FDA for human use. We believed that somewhere on this long list would be a few drugs or compounds that interact with the very same human proteins as the coronavirus.

We were right.

Our multidisciplinary team of researchers at the University of California, San Francisco, called the QCRG, identified 69 existing drugs and compounds with potential to treat COVID-19. A month ago, we began shipping boxes of these drugs off to Institut Pasteur in Paris and Mount Sinai in New York to see if they do in fact fight the coronavirus.

In the last four weeks, we have tested 47 of these drugs and compounds in the lab against live coronavirus. I’m happy to report we’ve identified some strong treatment leads and identified two separate mechanisms for how these drugs affect SARS-CoV-2 infection. Our findings were published on April 30 in the journal Nature...."
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